Giants maintain 100% record
Wigan failed to overcome the absence of Sam Tomkins as they slumped to a first defeat of the season at the hands of leaders Huddersfield, going down 22-10.
The Giants fought back from 10-0 down to secure another major scalp and take over at the top of Super League after three rounds with the only 100 per cent record.
Brett Ferres capped a terrific display by Paul Anderson's men with a 90-metre interception try in the last act of a pulsating encounter at the John Smith's Stadium.
Jamie Cording had earlier scored his first Super League try after Jermaine McGillvary had crossed as Huddersfield continued their impressive start to the season, which began with a stunning victory at St Helens.
Wigan's woes began before kick-off when Tomkins pulled out with a shoulder injury yet they initially made light of the absence of their talisman as they split the Huddersfield defence twice in as many minutes to surge into a 10-0 lead.
Second-rower Liam Farrell burrowed his way over for his third try in as many matches before taking Blake Green's defence-splitting pass to romp into space and send makeshift full-back Josh Charnley over. With Pat Richards adding a conversion, Huddersfield had shipped as many points in the first 11 minutes as they conceded in their first two matches.
A Brett Kearney hat-trick helped Bradford claim their second win of the season with a hard-fought 38-12 victory over a Castleford side that was reduced to 11 men at one stage.
The hosts held a 20-12 advantage when Justin Carney and Jamie Ellis were both sin-binned in quick succession for the visitors, allowing the Bulls to capitalise and extend their recent domination over their West Yorkshire neighbours at Odsal.
The Bulls have lost only twice in 18 games between the two since the inception of the Super League but, for much of this tough encounter, Castleford showed the resilience that had earned them a shock 14-12 triumph over champions Leeds last week.
Adam Sidlow, Matty Blythe and Chev Walker also crossed for the Bulls, with Ellis and Kirk Dixon the try-scorers for Castleford.
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