Uttoxeter passengers will have to live without trains to Derby during a huge £200 million re-signalling project.
The massive overhaul will take place at Derby Train Station from July 22 to October 7.
It means there will be no train services running to Derby from Uttoxeter Railway Station between July 22 and September 2.
After that, the trains will resume, but passengers can expect disruption and slower journey times until October 7.
While the trains are not running, replacement bus services will be available from Uttoxeter's station, off Bridge Street.
Bosses at train operator East Midlands Trains say the re-signalling work should improve journey times and efficiency at Derby station.
Some construction has already begun and between now and July, a 320-metre platform is being built.
In a letter to customers, Jake Kelly, managing director at East Midlands Trains, said: "Network Rail, East Midlands Trains and Cross Country are working in partnership to help passengers, businesses and communities understand the temporary changes to their journey.
"This joint approach means all passengers who will experience temporary changes to their journeys will receive simple, consistent and timely information to help them continue to travel with confidence while these works take place.
"A key part of this commitment is the launch of a dedicated new website.
"It includes a simple A-to-Z station directory, which provides detailed travel advice broken down by station and date to help passengers understand the temporary changes to their journeys, six months before works take place, regardless of whether they travel with CrossCountry or East Midlands Trains. It is available now at www.dby2018.co.uk .
"East Midlands Trains and CrossCountry services to and from Crewe, Matlock, Birmingham, Nottingham and Sheffield will be affected at different times while the work is carried out.
"Services to and from Nottingham and stations south of East Midlands Parkway on the main line to London are only marginally affected but you may still wish to understand these impacts as well as the details of the work taking place.
"It is also important to remember this investment is a key part of the biggest upgrade of the Midland Main Line since it opened in 1870, which will support better journeys between Leicester, Sheffield, Derby, Nottingham and London.
"Final timetables are not available yet but we are working hard to publish them as swiftly as possible."
Cross Country rail services from Burton Railway Station to Derby will also not run from July 22 to September 2, with bus and coach replacement services being brought in.
Services running to London, Crewe, Matlock and Nottingham are among those that will be impacted by the disruptions, with buses expected to be be brought regularly.
To help keep passengers informed of the latest developments and how their journeys will be affected, a new dedicated website has been launched - www.dby2018.co.uk
Full impact on services from the Derby station
CROSSCOUNTRY SERVICES
July 22 to September 2 - No services to/from Derby. Bus and coach replacement services operate from Chesterfield and Burton. Journey times will be extended on long distance services throughout the improvement work.
CREWE LINE
July 22 to September 2 - Bus and coach replacement service between Uttoxeter and Derby. Normal train service between Uttoxeter and Crewe.
DERBY TO NOTTINGHAM LINE
July 22 to July 29 - Reduced train service will operate.
July 30 to September 2 - Bus and coach replacement service between Nottingham and Derby
September 3 to October 7 - Trains between Nottingham and Derby. Bus and coach replacement service between Derby and Matlock.
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LONDON LINE
July 30 to October 7 - One train per hour to/from Sheffield and Chesterfield. One train per hour to/from Derby.
July 30 to September 3 - No direct services between Sheffield and Derby. Replacement coach service between Chesterfield and Derby.
August 13 to 19 - No direct trains between Derby and London. Coach replacement to East Midlands Parkway.
MATLOCK LINE
July 30 to August 24 - Services operate between Matlock and Derby only. No through services to/from Nottingham.
August 25 to October 7 - Bus and coach replacement service between Matlock and Derby.
